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The Nephron Loop Flashcards | Quizlet -The descending loop of the nephron loop is permeable to water, -water leaves by osmosis and returns to the blood, until it becomes isotonic, loop of henle ascending limb, -The wall of the loop is no longer permeable to water, but not impermeable to NaCl, -As NaCl leaves the filtrate in the ascending loop, Water leaves in what limb, Descending, Breaking down nephron functioning into six easy steps! The descending limb is only permeable to water. As the Loop of Henle descends from the cortex into the medulla, the concentration of salts in the interstitium increases (you will learn why that happens in the next step). As a result, the medulla is hypertonic to the filtrate, so water will diffuse out of the filtrate on the descending part of ... What for the ascending limb of loop of henle is permeable? What happens in the ascending limb of the loop of henle quizlet? Terms in this set (9) The ascending limb is impermeable to water. The desce...